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Duloxetine hydrochloride prices increased from 3.00 to 3.17 mg/mL," which came about as a result of number factors: • A recent change in U.S. Food and Drug Administration (FDA) guidance regarding the price of antidepressant medication. • The FDA's revision to its price guide prices that include a new "risk-based" approach to setting prices. • A revision to the guidance of Clinical Pharmacology Branch in this area as well. S.C.G.L., 2013 NCFDA CHP Price Guide, pg. 26 The FDA's Risk-Based Price Guide is a tool by which drug makers set prices. The guide assumes that pricing decisions (which can have a direct and immediate effect on the customer's health) are made on the basis of risk. Risk-based pricing was previously available in the United States, but price guide replaced it in 2007 with the updated guidance. Prior to the risk-based pricing guidance implemented in 2007, generic prices for many major antidepressants were based on the manufacturer's suggested retail prices (PRPs) and were significantly inflated. The price list for a given antidepressant sold across the globe in 2007 had following prescription antidepressant prices from the following manufacturers (US: Prozac, Lilly), listed in US dollars: Lilly's antidepressant prices increased from $16.99 to $24.29 Prozac's price increased from $21.98 to $27.25 Paxil's price increased from $14.99 to $19.38 Zoloft's price increased from $11.32 to $12.88 AstraZeneca's antidepressant pricing price decreased from $18.60 to $13.38 Effexor's antidepressant price increased from $14.97 to $16.34 Zyprexa's price decreased from $27.10 to $26.88 The FDA approved these medications: Prozac (fluoxetine), Paxil (paroxetine), Zoloft (avastin), Effexor (escitalopram), Zyprexa (olanzapine) and Apivox (lidocaine gels). The increased drug prices have been an increasing problem for drug companies. This is because the average price for a prescription antidepressant has remained relatively stable at around $15 per bottle since 2008 while its availability is declining; this has created a crisis for the pharmaceutical industry, as prices increase the risk of loss business. S.C.G.L., 2011 NCFDA CHP Price Guide, pg. 33 The pharmaceutical industry and government agencies have come together to try solve the problem of rising drug costs on prescription drugs. To this end, in 2011, the American Pharmaceutical Association, along with several public and private drug companies, created the Partnership Against Prescription Drug Abuse, a non-profit organization that has been working for the last five years to improve the health of communities in which it operates, as well the pharmaceutical industry, by promoting responsible use, safer prescribing and adherence. Additionally, government agencies are also taking the lead in creating a solution concerning the use of high-dose antidepressants such as "selective serotonin reuptake inhibitors (SSRIs)." The FDA's recent guidelines regarding these antidepressants have caused several changes to the use of these drugs and in the price of them. S.C.G.L., 2012 "Marijuana and the FDA: Drug Pricing Reform in Perspective." Medical Economics, vol. 28, pp. 6-8 Herein, the authors make a number of recommendations concerning the use prescription drugs. Most importantly, they advise that all health insurers a